Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50081908 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_53618 (CHEMBL663687) |
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pH | 7.2±n/a |
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Ki | 35481±n/a nM |
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Comments | extracted |
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Citation | Li, R; Hansch, C; Kaufman, BT A comparison of the inhibitory action of 5-(substituted-benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver. J Med Chem25:435-40 (1982) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | 1.5.1.3 | DHFR | DYR_CHICK |
Type: | n/a |
Mol. Mass.: | 21652.69 |
Organism: | Gallus gallus (Chicken) |
Description: | n/a |
Residue: | 189 |
Sequence: | VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSI
PEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAV
YKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFE
VYQKSVLAQ
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BDBM50081908 |
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n/a |
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Name | BDBM50081908 |
Synonyms: | 5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL18967 |
Type | Small organic molecule |
Emp. Form. | C12H14N4O |
Mol. Mass. | 230.2658 |
SMILES | COc1cccc(Cc2cnc(N)nc2N)c1 |
Structure |
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