| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-mannosidase 2 |
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| Ligand | BDBM50168995 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 5.75±0 |
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| Temperature | 298.15±0 K |
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| Ki | 3.0±0.0 nM |
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| IC50 | 37±0.0 nM |
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| Citation |  Kuntz, DA; Nakayama, S; Shea, K; Hori, H; Uto, Y; Nagasawa, H; Rose, DR Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II. Chembiochem11:673-80 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Alpha-mannosidase 2 |
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| Name: | Alpha-mannosidase 2 |
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| Synonyms: | Alpha-mannosidase 2 | GmII | Golgi alpha-mannosidase II | MAN2_DROME | alpha-Man-IIa |
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| Type: | Protein |
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| Mol. Mass.: | 126735.79 |
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| Organism: | Drosophila melanogaster (Fruit fly) |
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| Description: | Q24451 |
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| Residue: | 1108 |
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| Sequence: | MLRIRRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGE
EMRNLRARLAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDRMSFKDI
DGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRH
LHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRN
VLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKEL
AQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSC
PWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNY
ERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSG
YYTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQHHDGITGT
AKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVE
DSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWS
WHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPT
SLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGV
RSHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIR
NLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFI
EDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLE
KVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDL
DVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTPEEHTQKLDVCHLLPNVARCERTTLTFL
QNLEHLDGMVAPEVCPMETAAYVSSHSS
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| BDBM50168995 |
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| n/a |
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| Name | BDBM50168995 |
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| Synonyms: | (-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indolizine-1,2,8-triol | 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL | CHEMBL371197 | SWAINSONINE |
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| Type | Small organic molecule |
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| Emp. Form. | C8H15NO3 |
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| Mol. Mass. | 173.2096 |
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| SMILES | O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| |
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| Structure | 
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