| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50242259 |
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| Substrate/Competitor | n/a |
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| Ki | >10000±n/a nM |
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| Comments | PDSP_3172 |
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| Citation |  Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs. Psychopharmacology (Berl)162:193-202 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | Dopamine transporter | SC6A3_BOVIN | SLC6A3 | Sodium-dependent dopamine transporter |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 75707.43 |
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| Organism: | BOVINE |
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| Description: | Dopamine Transporter SLC6A3 BOVINE::P27922 |
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| Residue: | 693 |
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| Sequence: | MSEGRCSVAHMSSVVAPAKEANAMGPKAVELVLVKEQNGVQLTNSTLLNPPQSPTEAQDR
ETWSKKADFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVVAGVPLFYMELAL
GQFNREGAAGVWKICPILRGVGYTAILISLYIGFFYNVIIAWALHYLLSSFTTELPWTHC
NHSWNSPRCSDARAPNASSGPNGTSRTTPAAEYFERGVLHLHESQGIDDLGPPRWQLTSC
LVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLFALLLRGITLPGAVDAIRAYLSVDFH
RLCEASVWIDAAIQICFSLGVGLGVLIAFSSYNKFTNNCYRDAIITTSVNSLTSFSSGFV
VFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEALATLPLSSVWAVVFFVMLLTLGIDSA
MGGMESVITGLADEFQLLHRHRELFTLLVVLATFLLSLFCVTNGGIYVFTLLDHFAAGTS
ILFGVLMEVIGVAWFYGVWQFSDDIKQMTGRRPSLYWRLCWKFVSPCFLLFVVVVSIATF
RPPHYGAYVFPEWATALGWAIAASSMSVVPIYAAYKLCSLPGSSREKLAYAITPETEHGR
VDSGGGAPVHAPPLARGVGRWRKRKSCWVPSRGPGRGGPPTPSPRLAGHTRAFPWTGAPP
VPRELTPPSTCRCVPPLVCAHPAVESTGLCSVY
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| BDBM50242259 |
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| n/a |
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| Name | BDBM50242259 |
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| Synonyms: | CHEMBL516641 | HYPERFORIN |
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| Type | Small organic molecule |
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| Emp. Form. | C35H52O4 |
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| Mol. Mass. | 536.785 |
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| SMILES | [#6]-[#6](-[#6])-[#6](=O)[C@]12[#6](=O)-[#6](-[#6]\[#6]=[#6](/[#6])-[#6])-[#6](=O)[C@@]([#6]\[#6]=[#6](\[#6])-[#6])([#6]-[#6@H](-[#6]\[#6]=[#6](/[#6])-[#6])[C@@]1([#6])[#6]-[#6]\[#6]=[#6](/[#6])-[#6])[#6]2=O |r,THB:38:37:6.8.14:22.23.29| |
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| Structure | 
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