| Reaction Details |
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 | Report a problem with these data |
| Target | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Ligand | BDBM92781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CYP27B1 Inhibition Assay |
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| Ki | 3.34e+3± 3.8e+2 nM |
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| Citation |  Zhu, J; Barycki, R; Chiellini, G; Deluca, HF Screening of selective inhibitors of 1a,25-dihydroxyvitamin D3 24-hydroxylase using recombinant human enzyme expressed in Escherichia coli. Biochemistry49:10403-11 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Name: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Synonyms: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_HUMAN | CYP1ALPHA | CYP27B | CYP27B1 | Cytochrome P450 27B1 |
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| Type: | Protein |
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| Mol. Mass.: | 56522.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15528 |
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| Residue: | 508 |
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| Sequence: | MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR
LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR
QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP
ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH
WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE
ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS
ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA
QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP
EPGAAPVRPKTRTVLVPERSINLQFLDR
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| BDBM92781 |
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| n/a |
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| Name | BDBM92781 |
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| Synonyms: | CPA1 |
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| Type | Small molecule |
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| Emp. Form. | C27H43NO2 |
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| Mol. Mass. | 413.6358 |
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| SMILES | C[C@@H](CCCNC1CC1)C1CCC2\C(CCC[C@]12C)=C\C=C1\C[C@H](O)C(=C)[C@H](O)C1 |r| |
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| Structure | 
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