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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 8 | ||
| Ligand | BDBM102608 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Inhibition Assay | ||
| pH | 7.5±0 | ||
| IC50 | 15.9±n/a nM | ||
| Citation |  Gong, L; Han, X; Makra, F; Palmer, WS; Raptova, L Inhibitors of JNK US Patent US8536172 Publication Date 9/17/2013 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Mitogen-activated protein kinase 8 | |||
| Name: | Mitogen-activated protein kinase 8 | ||
| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48297.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
| Residue: | 427 | ||
| Sequence: |
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| BDBM102608 | |||
| n/a | |||
| Name | BDBM102608 | ||
| Synonyms: | US8536172, I-57 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H29N7O2 | ||
| Mol. Mass. | 459.5435 | ||
| SMILES | O[C@H]1CC[C@H](CC1)Nc1nccc(n1)-n1ccc2c(cccc12)N1CCN(CC1)C(=O)CC#N |r,wU:4.7,1.0,(-7.55,-4,;-7.55,-2.46,;-8.89,-1.69,;-8.89,-.15,;-7.55,.62,;-6.22,-.15,;-6.22,-1.69,;-7.55,2.16,;-6.22,2.93,;-6.22,4.47,;-4.89,5.24,;-3.55,4.47,;-3.55,2.93,;-4.89,2.16,;-2.22,2.16,;-.76,2.64,;.15,1.39,;-.76,.14,;-.44,-1.36,;-1.58,-2.39,;-3.04,-1.92,;-3.36,-.41,;-2.22,.62,;1.05,-1.76,;1.45,-3.25,;2.94,-3.65,;4.03,-2.56,;3.63,-1.07,;2.14,-.67,;5.51,-2.96,;6.6,-1.87,;5.91,-4.44,;7.4,-4.84,;8.89,-5.24,)| | ||
| Structure | 
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