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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 8 | ||
| Ligand | BDBM102591 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Inhibition Assay | ||
| pH | 7.5±0 | ||
| IC50 | 35±n/a nM | ||
| Citation |  Gong, L; Han, X; Makra, F; Palmer, WS; Raptova, L Inhibitors of JNK US Patent US8536172 Publication Date 9/17/2013 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Mitogen-activated protein kinase 8 | |||
| Name: | Mitogen-activated protein kinase 8 | ||
| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48297.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
| Residue: | 427 | ||
| Sequence: |
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| BDBM102591 | |||
| n/a | |||
| Name | BDBM102591 | ||
| Synonyms: | US8536172, I-40 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H35N7O3 | ||
| Mol. Mass. | 517.6226 | ||
| SMILES | COCCO[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-n1ccc2c(cccc12)N1CCN(CC1)C(=O)CC#N |r,wU:8.11,wD:5.4,(-9.7,-6.93,;-9.7,-5.39,;-8.37,-4.62,;-8.37,-3.08,;-7.03,-2.31,;-7.03,-.77,;-5.7,,;-5.7,1.54,;-7.03,2.31,;-8.37,1.54,;-8.37,,;-7.03,3.85,;-5.7,4.62,;-5.7,6.16,;-4.37,6.93,;-3.03,6.16,;-3.03,4.62,;-4.37,3.85,;-1.7,3.85,;-.23,4.33,;.67,3.08,;-.23,1.83,;.09,.33,;-1.06,-.7,;-2.52,-.23,;-2.84,1.28,;-1.7,2.31,;1.57,-.07,;1.97,-1.56,;3.46,-1.96,;4.55,-.87,;4.15,.62,;2.66,1.02,;6.04,-1.27,;6.43,-2.75,;7.12,-.18,;8.61,-.58,;9.7,.51,)| | ||
| Structure | 
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