| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2C9 |
|---|
| Ligand | BDBM50353392 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay Example 7 |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 3.1e+3±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Claremon, DA; Zhuang, L; Leftheris, K; Tice, CM; Ye, Y; Singh, SB; Himmelsbach, F Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1 US Patent US8592410 Publication Date 11/26/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2C9 |
|---|
| Name: | Cytochrome P450 2C9 |
|---|
| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55636.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11712 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
|
|
|
|---|
| BDBM50353392 |
|---|
| n/a |
|---|
| Name | BDBM50353392 |
|---|
| Synonyms: | CHEMBL1829761 | US8575157, 197 | US8592410, Comparator 9 | US8598163, 67 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H28FNO3 |
|---|
| Mol. Mass. | 433.5145 |
|---|
| SMILES | C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
