| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM112691 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 16.1±n/a nM |
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| Comments | extracted |
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| Citation |  Guzzo, PR; Surman, MD; Henderson, AJ; Hadden, M; Freeman, EE Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof US Patent US8629158 Publication Date 1/14/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM112691 |
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| n/a |
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| Name | BDBM112691 |
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| Synonyms: | US8629158, 16 | US8629158, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21F3N4O |
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| Mol. Mass. | 450.4556 |
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| SMILES | Cn1c2CC3CCC(N3)c2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(cn1)C(F)(F)F |THB:10:9:8:6.5,1:2:8:6.5| |
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| Structure | 
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