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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 14 | ||
| Ligand | BDBM158704 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.2±n/a | ||
| Ki | 22±n/a nM | ||
| Comments | extracted | ||
| Citation |  Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 14 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
| Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
| Type: | Protein | ||
| Mol. Mass.: | 104059.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99558 | ||
| Residue: | 947 | ||
| Sequence: |
| ||
| BDBM158704 | |||
| n/a | |||
| Name | BDBM158704 | ||
| Synonyms: | US9034866, 179 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H19N3O2 | ||
| Mol. Mass. | 321.3731 | ||
| SMILES | CC(C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O |(6.19,-.05,;4.85,.72,;6.19,1.49,;4.85,2.26,;3.52,-.05,;2.18,-.82,;.85,-1.59,;.85,-3.13,;-.48,-3.9,;-1.82,-3.13,;-3.02,-4.09,;-4.52,-3.75,;-5.19,-2.36,;-3.58,-2.59,;-4.52,-.97,;-5.31,.35,;-4.3,1.51,;-2.88,.91,;-3.02,-.63,;-1.82,-1.59,;-.48,-.82,;-4.7,3,;-3.61,4.09,;-6.19,3.4,)| | ||
| Structure | 
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