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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM177199 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 2100±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
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| BDBM177199 | |||
| n/a | |||
| Name | BDBM177199 | ||
| Synonyms: | US9120749, 565 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H24Cl2FN3O2 | ||
| Mol. Mass. | 488.381 | ||
| SMILES | N[C@H]1CC[C@@H](CC1)Nc1c(cnc2c(F)cc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1 |r,wU:4.7,wD:1.0,(-2.46,5.26,;-1.37,4.17,;-1.77,2.68,;-.68,1.59,;.81,1.99,;1.21,3.48,;.12,4.57,;1.9,.9,;1.9,-.64,;3.23,-1.41,;3.23,-2.95,;1.9,-3.72,;.56,-2.95,;-.77,-3.72,;-.77,-5.26,;-2.1,-2.95,;-2.1,-1.41,;-.77,-.64,;.56,-1.41,;-3.44,-.64,;-3.44,.9,;-4.77,1.67,;-4.77,3.21,;-6.1,.9,;-7.44,1.67,;-6.1,-.64,;-7.44,-1.41,;-4.77,-1.41,;4.56,-.64,;4.56,.9,;5.9,-1.41,;6.67,-2.74,;7.44,-1.41,)| | ||
| Structure | 
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