| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase tankyrase-2 [959-1164] |
|---|
| Ligand | BDBM50439810 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 1030±70 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Cheung, AK; Chin, DN; Fan, J; Shultz, MD; Tomlinson, RC 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors US Patent US9227982 Publication Date 1/5/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Poly [ADP-ribose] polymerase tankyrase-2 [959-1164] |
|---|
| Name: | Poly [ADP-ribose] polymerase tankyrase-2 [959-1164] |
|---|
| Synonyms: | PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase 2 PARP catalytic domain (TNKS2P) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 23526.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H2K2[959-1164] |
|---|
| Residue: | 206 |
|---|
| Sequence: | SPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSE
ENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGG
TGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAE
YVIYRGEQAYPEYLITYQIMRPEGMV
|
|
|
|---|
| BDBM50439810 |
|---|
| n/a |
|---|
| Name | BDBM50439810 |
|---|
| Synonyms: | CHEMBL2419716 | US9227982, 18 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N3O3S |
|---|
| Mol. Mass. | 409.501 |
|---|
| SMILES | O=C(CCc1ccccc1)N(Cc1ccsc1)Cc1nc2CCOCc2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
