| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
|---|
| Ligand | BDBM289613 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | IMAP TR-FRET assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| EC50 | 550±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Branstetter, B; Breitenbucher, J; Dyck, B; Gomez, L; Hudson, AR; Marrone, TJ; Peters, M; Vickers, T Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds US Patent US10092575 Publication Date 10/9/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
|---|
| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
|---|
| Synonyms: | 63 kDa Cam-PDE | Calcium/calmodulin-dependent 3 ,5 -cyclic nucleotide phosphodiesterase 1B | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDE1B_HUMAN | PDES1B | Phosphodiesterase 1B | Phosphodiesterase 1B (PDE1B1) | Phosphodiesterase Type 1 (PDE1B) | Phosphodiesterase, PDE1/PDE5 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 61366.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 536 |
|---|
| Sequence: | MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP
KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL
RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL
RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV
FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK
ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS
QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS
FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
|
|
|
|---|
| BDBM289613 |
|---|
| n/a |
|---|
| Name | BDBM289613 |
|---|
| Synonyms: | 6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one | US10092575, Example 101 | US10376514, Example 101 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H16ClN5OS |
|---|
| Mol. Mass. | 385.871 |
|---|
| SMILES | CN1CCc2c(C1)sc1n(Cc3ccc(Cl)cc3)c(=O)n3ncnc3c21 |
|---|
| Structure | 
|
|---|
Search and Browse
