Found 2498 hits with Last Name = 'vickers' and Initial = 't' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190927
(CHEMBL214513 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES CCc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1 Show InChI InChI=1S/C31H44N4O2S/c1-5-22-6-8-23(9-7-22)27-10-11-28(38-27)29(36)33(4)26-15-19-35(21-26)30(37)34-18-14-25(20-34)32-24-12-16-31(2,3)17-13-24/h6-11,24-26,32H,5,12-21H2,1-4H3/t25-,26+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190919
(CHEMBL386454 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES COc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1 Show InChI InChI=1S/C30H42N4O3S/c1-30(2)15-11-22(12-16-30)31-23-13-17-33(19-23)29(36)34-18-14-24(20-34)32(3)28(35)27-10-9-26(38-27)21-5-7-25(37-4)8-6-21/h5-10,22-24,31H,11-20H2,1-4H3/t23-,24+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168622
((S)-3-{[5-(4-Ethyl-phenyl)-thiophene-2-carbonyl]-m...)Show SMILES CCc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N(C)[C@@H]1CCN(C)C1 Show InChI InChI=1S/C25H34N4O2S/c1-5-18-6-8-19(9-7-18)22-10-11-23(32-22)24(30)27(3)21-13-15-29(17-21)25(31)28(4)20-12-14-26(2)16-20/h6-11,20-21H,5,12-17H2,1-4H3/t20-,21+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168624
((S)-3-{[5-(2-Chloro-4-methyl-phenyl)-thiophene-2-c...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccc(C)cc1Cl Show InChI InChI=1S/C24H31ClN4O2S/c1-16-5-6-19(20(25)13-16)21-7-8-22(32-21)23(30)27(3)18-10-12-29(15-18)24(31)28(4)17-9-11-26(2)14-17/h5-8,13,17-18H,9-12,14-15H2,1-4H3/t17-,18+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50206687
((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)Show SMILES CN([C@H]1CCN(C1)C1CCC1)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H30ClN5O2S/c1-29(20-9-11-30(14-20)19-3-2-4-19)26(34)31-12-10-21(15-31)32-16-28-22-13-23(35-24(22)25(32)33)17-5-7-18(27)8-6-17/h5-8,13,16,19-21H,2-4,9-12,14-15H2,1H3/t20-,21-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 17: 2535-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.012
BindingDB Entry DOI: 10.7270/Q23778CV |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189587
((S)-6-(4-chlorophenyl)-2-(6-(3-(dimethylamino)pyrr...)Show SMILES CN(C)[C@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(ccc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H24ClN5O/c1-29(2)22-11-12-30(16-22)24-10-8-21(15-27-24)31-25(32)23-9-5-18(13-19(23)14-28-31)17-3-6-20(26)7-4-17/h3-10,13-15,22H,11-12,16H2,1-2H3/t22-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189584
((R)-6-(4-chlorophenyl)-2-(6-(3-(dimethylamino)pyrr...)Show SMILES CN(C)[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(ccc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H24ClN5O/c1-29(2)22-11-12-30(16-22)24-10-8-21(15-27-24)31-25(32)23-9-5-18(13-19(23)14-28-31)17-3-6-20(26)7-4-17/h3-10,13-15,22H,11-12,16H2,1-2H3/t22-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189581
((S)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrol...)Show SMILES CN[C@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(ccc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H22ClN5O/c1-26-20-10-11-29(15-20)23-9-7-21(14-27-23)30-24(31)22-8-4-17(12-18(22)13-28-30)16-2-5-19(25)6-3-16/h2-9,12-14,20,26H,10-11,15H2,1H3/t20-/m0/s1 | Reactome pathway
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189592
((R)-2-(4-methoxyphenyl)-6-(6-(3-(methylamino)pyrro...)Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(OC)cc1 Show InChI InChI=1S/C23H23N5O2S/c1-24-17-9-10-27(14-17)21-8-5-18(13-25-21)28-23(29)22-16(12-26-28)11-20(31-22)15-3-6-19(30-2)7-4-15/h3-8,11-13,17,24H,9-10,14H2,1-2H3/t17-/m1/s1 | Reactome pathway
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189589
((R)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrol...)Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(ccc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H22ClN5O/c1-26-20-10-11-29(15-20)23-9-7-21(14-27-23)30-24(31)22-8-4-17(12-18(22)13-28-30)16-2-5-19(25)6-3-16/h2-9,12-14,20,26H,10-11,15H2,1H3/t20-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190948
(CHEMBL442064 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES CN([C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1)C(=O)c1ccc(s1)-c1ccc(C)cc1 Show InChI InChI=1S/C30H42N4O2S/c1-21-5-7-22(8-6-21)26-9-10-27(37-26)28(35)32(4)25-14-18-34(20-25)29(36)33-17-13-24(19-33)31-23-11-15-30(2,3)16-12-23/h5-10,23-25,31H,11-20H2,1-4H3/t24-,25+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189582
((S)-6-(4-chlorophenyl)-2-(6-(3-(pyrrolidin-1-ylami...)Show SMILES Clc1ccc(cc1)-c1ccc2c(cnn(-c3ccc(nc3)N3CC[C@@H](C3)NN3CCCC3)c2=O)c1 Show InChI InChI=1S/C27H27ClN6O/c28-22-6-3-19(4-7-22)20-5-9-25-21(15-20)16-30-34(27(25)35)24-8-10-26(29-17-24)32-14-11-23(18-32)31-33-12-1-2-13-33/h3-10,15-17,23,31H,1-2,11-14,18H2/t23-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50160730
(3-{(S)-Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...)Show SMILES CN([C@@H]1CCN(C1)C1CCC(C)(C)CC1)C(=O)N1CCC(C1)N(C)C(=O)c1ccc(s1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C31H41F3N4O2S/c1-30(2)15-11-23(12-16-30)37-17-13-25(19-37)36(4)29(40)38-18-14-24(20-38)35(3)28(39)27-10-9-26(41-27)21-5-7-22(8-6-21)31(32,33)34/h5-10,23-25H,11-20H2,1-4H3/t24?,25-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells |
Bioorg Med Chem Lett 15: 999-1004 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.036
BindingDB Entry DOI: 10.7270/Q21R6R9X |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189579
((S)-6-(4-chlorophenyl)-2-(6-(3-(ethylamino)pyrroli...)Show SMILES CCN[C@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(ccc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H24ClN5O/c1-2-27-21-11-12-30(16-21)24-10-8-22(15-28-24)31-25(32)23-9-5-18(13-19(23)14-29-31)17-3-6-20(26)7-4-17/h3-10,13-15,21,27H,2,11-12,16H2,1H3/t21-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190943
(5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-((S)-1-(...)Show SMILES CN([C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1)C(=O)c1ccc(s1)-c1ccc2OCCOc2c1 Show InChI InChI=1S/C31H42N4O4S/c1-31(2)12-8-22(9-13-31)32-23-10-14-34(19-23)30(37)35-15-11-24(20-35)33(3)29(36)28-7-6-27(40-28)21-4-5-25-26(18-21)39-17-16-38-25/h4-7,18,22-24,32H,8-17,19-20H2,1-3H3/t23-,24+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189578
((R)-2-(4-chlorophenyl)-6-(6-(3-(methylamino)pyrrol...)Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H20ClN5OS/c1-24-17-8-9-27(13-17)20-7-6-18(12-25-20)28-22(29)21-15(11-26-28)10-19(30-21)14-2-4-16(23)5-3-14/h2-7,10-12,17,24H,8-9,13H2,1H3/t17-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50206675
((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)Show SMILES CN([C@H]1CCN(C1)C1CCC(C)(C)CC1)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C30H38ClN5O2S/c1-30(2)12-8-22(9-13-30)34-14-10-23(17-34)33(3)29(38)35-15-11-24(18-35)36-19-32-25-16-26(39-27(25)28(36)37)20-4-6-21(31)7-5-20/h4-7,16,19,22-24H,8-15,17-18H2,1-3H3/t23-,24-/m0/s1 | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 17: 2535-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.012
BindingDB Entry DOI: 10.7270/Q23778CV |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168611
((S)-3-{Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H29F3N4O2S/c1-28-12-10-18(14-28)30(3)23(33)31-13-11-19(15-31)29(2)22(32)21-9-8-20(34-21)16-4-6-17(7-5-16)24(25,26)27/h4-9,18-19H,10-15H2,1-3H3/t18-,19+/m1/s1 | Reactome pathway
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168615
((S)-3-[(4'-Chloro-biphenyl-4-carbonyl)-methyl-amin...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H31ClN4O2/c1-27-14-12-22(16-27)29(3)25(32)30-15-13-23(17-30)28(2)24(31)20-6-4-18(5-7-20)19-8-10-21(26)11-9-19/h4-11,22-23H,12-17H2,1-3H3/t22-,23+/m1/s1 | Reactome pathway
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PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168616
((S)-3-{[5-(2-Chloro-4-ethoxy-phenyl)-thiophene-2-c...)Show SMILES CCOc1ccc(-c2ccc(s2)C(=O)N(C)[C@H]2CCN(C2)C(=O)N(C)[C@@H]2CCN(C)C2)c(Cl)c1 Show InChI InChI=1S/C25H33ClN4O3S/c1-5-33-19-6-7-20(21(26)14-19)22-8-9-23(34-22)24(31)28(3)18-11-13-30(16-18)25(32)29(4)17-10-12-27(2)15-17/h6-9,14,17-18H,5,10-13,15-16H2,1-4H3/t17-,18+/m1/s1 | Reactome pathway
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UniChem
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168618
((S)-3-{[5-(4-Chloro-phenyl)-thiophene-2-carbonyl]-...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H29ClN4O2S/c1-25-12-10-18(14-25)27(3)23(30)28-13-11-19(15-28)26(2)22(29)21-9-8-20(31-21)16-4-6-17(24)7-5-16/h4-9,18-19H,10-15H2,1-3H3/t18-,19+/m1/s1 | Reactome pathway
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189593
((S)-2-(4-fluorophenyl)-6-(6-(3-(methylamino)pyrrol...)Show SMILES CN[C@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20FN5OS/c1-24-17-8-9-27(13-17)20-7-6-18(12-25-20)28-22(29)21-15(11-26-28)10-19(30-21)14-2-4-16(23)5-3-14/h2-7,10-12,17,24H,8-9,13H2,1H3/t17-/m0/s1 | Reactome pathway
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190922
(5-(4-ethylphenyl)-N-methyl-N-((S)-1-((R)-3-(tetrah...)Show SMILES CCc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCOCC1 Show InChI InChI=1S/C28H38N4O3S/c1-3-20-4-6-21(7-5-20)25-8-9-26(36-25)27(33)30(2)24-11-15-32(19-24)28(34)31-14-10-23(18-31)29-22-12-16-35-17-13-22/h4-9,22-24,29H,3,10-19H2,1-2H3/t23-,24+/m1/s1 | Reactome pathway
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190931
(CHEMBL265255 | N-((S)-1-((R)-3-(cyclopentylamino)p...)Show SMILES CCc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCCC1 Show InChI InChI=1S/C28H38N4O2S/c1-3-20-8-10-21(11-9-20)25-12-13-26(35-25)27(33)30(2)24-15-17-32(19-24)28(34)31-16-14-23(18-31)29-22-6-4-5-7-22/h8-13,22-24,29H,3-7,14-19H2,1-2H3/t23-,24+/m1/s1 | Reactome pathway
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190941
(CHEMBL387013 | N-((S)-1-((R)-3-(3-cyclohexylpropyl...)Show SMILES COc1ccc(-c2ccc(s2)C(=O)N(C)[C@H]2CCN(C2)C(=O)N2CC[C@H](C2)NCCCC2CCCCC2)c(C)c1 Show InChI InChI=1S/C32H46N4O3S/c1-23-20-27(39-3)11-12-28(23)29-13-14-30(40-29)31(37)34(2)26-16-19-36(22-26)32(38)35-18-15-25(21-35)33-17-7-10-24-8-5-4-6-9-24/h11-14,20,24-26,33H,4-10,15-19,21-22H2,1-3H3/t25-,26+/m1/s1 | Reactome pathway
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| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190940
(CHEMBL383933 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES COc1ccc(-c2ccc(s2)C(=O)N(C)[C@H]2CCN(C2)C(=O)N2CC[C@H](C2)NC2CCC(C)(C)CC2)c(C)c1 Show InChI InChI=1S/C31H44N4O3S/c1-21-18-25(38-5)6-7-26(21)27-8-9-28(39-27)29(36)33(4)24-13-17-35(20-24)30(37)34-16-12-23(19-34)32-22-10-14-31(2,3)15-11-22/h6-9,18,22-24,32H,10-17,19-20H2,1-5H3/t23-,24+/m1/s1 | Reactome pathway
KEGG
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| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189594
((R)-2-(4-fluorophenyl)-6-(6-(3-(methylamino)pyrrol...)Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20FN5OS/c1-24-17-8-9-27(13-17)20-7-6-18(12-25-20)28-22(29)21-15(11-26-28)10-19(30-21)14-2-4-16(23)5-3-14/h2-7,10-12,17,24H,8-9,13H2,1H3/t17-/m1/s1 | Reactome pathway
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189591
((R)-2-(4-ethylphenyl)-6-(6-(3-(methylamino)pyrroli...)Show SMILES CCc1ccc(cc1)-c1cc2cnn(-c3ccc(nc3)N3CC[C@H](C3)NC)c(=O)c2s1 Show InChI InChI=1S/C24H25N5OS/c1-3-16-4-6-17(7-5-16)21-12-18-13-27-29(24(30)23(18)31-21)20-8-9-22(26-14-20)28-11-10-19(15-28)25-2/h4-9,12-14,19,25H,3,10-11,15H2,1-2H3/t19-/m1/s1 | Reactome pathway
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| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50206666
((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)Show SMILES CN([C@H]1CCN(C1)C1CCOCC1)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C27H32ClN5O3S/c1-30(21-6-10-31(15-21)20-8-12-36-13-9-20)27(35)32-11-7-22(16-32)33-17-29-23-14-24(37-25(23)26(33)34)18-2-4-19(28)5-3-18/h2-5,14,17,20-22H,6-13,15-16H2,1H3/t21-,22-/m0/s1 | Reactome pathway
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 17: 2535-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.012
BindingDB Entry DOI: 10.7270/Q23778CV |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50206679
((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)Show SMILES CN([C@H]1CCN(CC2CC2)C1)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H30ClN5O2S/c1-29(20-8-10-30(14-20)13-17-2-3-17)26(34)31-11-9-21(15-31)32-16-28-22-12-23(35-24(22)25(32)33)18-4-6-19(27)7-5-18/h4-7,12,16-17,20-21H,2-3,8-11,13-15H2,1H3/t20-,21-/m0/s1 | Reactome pathway
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 17: 2535-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.012
BindingDB Entry DOI: 10.7270/Q23778CV |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168605
((S)-3-{[5-(4-Chloro-2-methyl-phenyl)-thiophene-2-c...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccc(Cl)cc1C Show InChI InChI=1S/C24H31ClN4O2S/c1-16-13-17(25)5-6-20(16)21-7-8-22(32-21)23(30)27(3)19-10-12-29(15-19)24(31)28(4)18-9-11-26(2)14-18/h5-8,13,18-19H,9-12,14-15H2,1-4H3/t18-,19+/m1/s1 | Reactome pathway
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PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168623
((S)-3-{[5-(2,4-Dichloro-phenyl)-thiophene-2-carbon...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C23H28Cl2N4O2S/c1-26-10-8-16(13-26)28(3)23(31)29-11-9-17(14-29)27(2)22(30)21-7-6-20(32-21)18-5-4-15(24)12-19(18)25/h4-7,12,16-17H,8-11,13-14H2,1-3H3/t16-,17+/m1/s1 | Reactome pathway
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PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168633
((S)-3-[Methyl-(5-p-tolyl-thiophene-2-carbonyl)-ami...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccc(C)cc1 Show InChI InChI=1S/C24H32N4O2S/c1-17-5-7-18(8-6-17)21-9-10-22(31-21)23(29)26(3)20-12-14-28(16-20)24(30)27(4)19-11-13-25(2)15-19/h5-10,19-20H,11-16H2,1-4H3/t19-,20+/m1/s1 | Reactome pathway
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PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168630
((S)-3-{[5-(2,4-Dimethyl-phenyl)-thiophene-2-carbon...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccc(C)cc1C Show InChI InChI=1S/C25H34N4O2S/c1-17-6-7-21(18(2)14-17)22-8-9-23(32-22)24(30)27(4)20-11-13-29(16-20)25(31)28(5)19-10-12-26(3)15-19/h6-9,14,19-20H,10-13,15-16H2,1-5H3/t19-,20+/m1/s1 | Reactome pathway
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| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190929
(5-(4-ethylphenyl)-N-methyl-N-((S)-1-((R)-3-(methyl...)Show SMILES CCc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)N(C)C1CCOCC1 Show InChI InChI=1S/C29H40N4O3S/c1-4-21-5-7-22(8-6-21)26-9-10-27(37-26)28(34)31(3)25-12-16-33(20-25)29(35)32-15-11-24(19-32)30(2)23-13-17-36-18-14-23/h5-10,23-25H,4,11-20H2,1-3H3/t24-,25+/m1/s1 | Reactome pathway
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PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168635
((S)-3-{[5-(4-Methoxy-2-methyl-phenyl)-thiophene-2-...)Show SMILES COc1ccc(-c2ccc(s2)C(=O)N(C)[C@H]2CCN(C2)C(=O)N(C)[C@@H]2CCN(C)C2)c(C)c1 Show InChI InChI=1S/C25H34N4O3S/c1-17-14-20(32-5)6-7-21(17)22-8-9-23(33-22)24(30)27(3)19-11-13-29(16-19)25(31)28(4)18-10-12-26(2)15-18/h6-9,14,18-19H,10-13,15-16H2,1-5H3/t18-,19+/m1/s1 | Reactome pathway
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189586
((S)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)Show SMILES CN[C@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H20F3N5OS/c1-27-17-8-9-30(13-17)20-7-6-18(12-28-20)31-22(32)21-15(11-29-31)10-19(33-21)14-2-4-16(5-3-14)23(24,25)26/h2-7,10-12,17,27H,8-9,13H2,1H3/t17-/m0/s1 | Reactome pathway
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| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189576
((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H20F3N5OS/c1-27-17-8-9-30(13-17)20-7-6-18(12-28-20)31-22(32)21-15(11-29-31)10-19(33-21)14-2-4-16(5-3-14)23(24,25)26/h2-7,10-12,17,27H,8-9,13H2,1H3/t17-/m1/s1 | Reactome pathway
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| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190918
(CHEMBL215067 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES CN([C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1)C(=O)c1ccc(s1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C30H39F3N4O2S/c1-29(2)14-10-22(11-15-29)34-23-12-16-36(18-23)28(39)37-17-13-24(19-37)35(3)27(38)26-9-8-25(40-26)20-4-6-21(7-5-20)30(31,32)33/h4-9,22-24,34H,10-19H2,1-3H3/t23-,24+/m1/s1 | Reactome pathway
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| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50206677
((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)Show SMILES CN([C@H]1CCN(C1)C1CCCC1)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C27H32ClN5O2S/c1-30(21-10-12-31(15-21)20-4-2-3-5-20)27(35)32-13-11-22(16-32)33-17-29-23-14-24(36-25(23)26(33)34)18-6-8-19(28)9-7-18/h6-9,14,17,20-22H,2-5,10-13,15-16H2,1H3/t21-,22-/m0/s1 | Reactome pathway
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 17: 2535-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.012
BindingDB Entry DOI: 10.7270/Q23778CV |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50206681
((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)Show SMILES CN([C@H]1CCN(Cc2ccoc2)C1)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C27H28ClN5O3S/c1-30(21-6-9-31(14-21)13-18-8-11-36-16-18)27(35)32-10-7-22(15-32)33-17-29-23-12-24(37-25(23)26(33)34)19-2-4-20(28)5-3-19/h2-5,8,11-12,16-17,21-22H,6-7,9-10,13-15H2,1H3/t21-,22-/m0/s1 | Reactome pathway
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 17: 2535-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.012
BindingDB Entry DOI: 10.7270/Q23778CV |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168631
((S)-3-{Methyl-[5-(4-trifluoromethoxy-phenyl)-thiop...)Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C24H29F3N4O3S/c1-28-12-10-17(14-28)30(3)23(33)31-13-11-18(15-31)29(2)22(32)21-9-8-20(35-21)16-4-6-19(7-5-16)34-24(25,26)27/h4-9,17-18H,10-15H2,1-3H3/t17-,18+/m1/s1 | Reactome pathway
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168628
((S)-3-{[5-(4-Methoxy-phenyl)-thiophene-2-carbonyl]...)Show SMILES COc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N(C)[C@@H]1CCN(C)C1 Show InChI InChI=1S/C24H32N4O3S/c1-25-13-11-18(15-25)27(3)24(30)28-14-12-19(16-28)26(2)23(29)22-10-9-21(32-22)17-5-7-20(31-4)8-6-17/h5-10,18-19H,11-16H2,1-4H3/t18-,19+/m1/s1 | Reactome pathway
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ... |
Bioorg Med Chem Lett 15: 3439-45 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190268
(4'-methylsulfanyl-biphenyl-4-carboxylic acid methy...)Show SMILES CSc1ccc(cc1)-c1ccc(cc1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@@H](C1)NCCCc1ccccc1 Show InChI InChI=1S/C33H40N4O2S/c1-35(32(38)28-12-10-26(11-13-28)27-14-16-31(40-2)17-15-27)30-19-22-37(24-30)33(39)36-21-18-29(23-36)34-20-6-9-25-7-4-3-5-8-25/h3-5,7-8,10-17,29-30,34H,6,9,18-24H2,1-2H3/t29-,30-/m0/s1 | Reactome pathway
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-Tyr13]MCH from human MCHR1 expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 4450-7 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.045
BindingDB Entry DOI: 10.7270/Q23J3CKC |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190925
(4'-Ethyl-biphenyl-4-carboxylic acid methyl-[(S)-1-...)Show SMILES CCc1ccc(cc1)-c1ccc(cc1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)N1CCCCC1 Show InChI InChI=1S/C30H40N4O2/c1-3-23-7-9-24(10-8-23)25-11-13-26(14-12-25)29(35)31(2)27-15-19-33(21-27)30(36)34-20-16-28(22-34)32-17-5-4-6-18-32/h7-14,27-28H,3-6,15-22H2,1-2H3/t27-,28+/m0/s1 | Reactome pathway
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50206690
((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)Show SMILES CN([C@H]1CCN(CC2CCOC2)C1)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 |w:7.6| Show InChI InChI=1S/C27H32ClN5O3S/c1-30(21-6-9-31(14-21)13-18-8-11-36-16-18)27(35)32-10-7-22(15-32)33-17-29-23-12-24(37-25(23)26(33)34)19-2-4-20(28)5-3-19/h2-5,12,17-18,21-22H,6-11,13-16H2,1H3/t18?,21-,22-/m0/s1 | Reactome pathway
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 17: 2535-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.012
BindingDB Entry DOI: 10.7270/Q23778CV |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190920
(4'-ethyl-biphenyl-4-carboxylic acid {(S)-1-[(R)-3-...)Show SMILES CCc1ccc(cc1)-c1ccc(cc1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)N[C@@H](C)C(C)C Show InChI InChI=1S/C30H42N4O2/c1-6-23-7-9-24(10-8-23)25-11-13-26(14-12-25)29(35)32(5)28-16-18-34(20-28)30(36)33-17-15-27(19-33)31-22(4)21(2)3/h7-14,21-22,27-28,31H,6,15-20H2,1-5H3/t22-,27+,28-/m0/s1 | Reactome pathway
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189583
((S)-6-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin...)Show SMILES CN(C)[C@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H22F3N5OS/c1-30(2)19-9-10-31(14-19)21-8-7-18(13-28-21)32-23(33)22-16(12-29-32)11-20(34-22)15-3-5-17(6-4-15)24(25,26)27/h3-8,11-13,19H,9-10,14H2,1-2H3/t19-/m0/s1 | Reactome pathway
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| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c
BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190947
(4'-ethyl-biphenyl-4-carboxylic acid {(S)-1-[(R)-3-...)Show SMILES CCc1ccc(cc1)-c1ccc(cc1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NCCCC1CCCCC1 Show InChI InChI=1S/C34H48N4O2/c1-3-26-11-13-28(14-12-26)29-15-17-30(18-16-29)33(39)36(2)32-20-23-38(25-32)34(40)37-22-19-31(24-37)35-21-7-10-27-8-5-4-6-9-27/h11-18,27,31-32,35H,3-10,19-25H2,1-2H3/t31-,32+/m1/s1 | Reactome pathway
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| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049
BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50206673
((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)Show SMILES CC(C)N1CC[C@@H](C1)N(C)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H30ClN5O2S/c1-16(2)29-10-8-19(13-29)28(3)25(33)30-11-9-20(14-30)31-15-27-21-12-22(34-23(21)24(31)32)17-4-6-18(26)7-5-17/h4-7,12,15-16,19-20H,8-11,13-14H2,1-3H3/t19-,20-/m0/s1 | Reactome pathway
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 17: 2535-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.012
BindingDB Entry DOI: 10.7270/Q23778CV |
More data for this
Ligand-Target Pair | |
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