Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM289871 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 1.20±n/a nM |
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Comments | extracted |
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Citation | Abeywardane, A; Broadwater, J; Brunette, SR; Kirrane, Jr., TM; Razavi, H; Sibley, R; Smith Keenan, LL; Zhang, Q Inhibitors of leukotriene production US Patent US9573957 Publication Date 2/21/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM289871 |
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n/a |
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Name | BDBM289871 |
Synonyms: | (S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-naphthalen-2-ylmethyl}- piperidin-3-ol | US9573957, Example 14 |
Type | Small organic molecule |
Emp. Form. | C24H24N4O2 |
Mol. Mass. | 400.473 |
SMILES | O[C@H]1CCCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 |r| |
Structure |
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