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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM229391 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF Biochemical Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.1±n/a nM | ||
| Comments | extracted | ||
| Citation |  Brubaker, J; Childers, ML; Christopher, M; Close, JT; Katz, JD; Jung, J; Peterson, S; Siliphaivanh, P; Siu, T; Smith, GF; Torres, LE; Woo, HC; Young, JR; Zhang, H Cyanomethylpyrazole carboxamides as janus kinase inhibitors US Patent US9328099 Publication Date 5/3/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM229391 | |||
| n/a | |||
| Name | BDBM229391 | ||
| Synonyms: | US9328099, 39-2 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24F4N6O | ||
| Mol. Mass. | 464.4592 | ||
| SMILES | NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)C1(CC#N)CCC(CC1)N1CC(F)C1 |(4.72,5.14,;3.23,4.74,;2.14,5.83,;2.83,3.25,;1.37,2.78,;1.37,1.24,;2.83,.76,;3.74,2.01,;5.22,1.61,;5.62,.12,;7.11,-.28,;7.51,-1.77,;6.42,-2.85,;4.93,-2.46,;4.53,-.97,;6.82,-4.34,;5.73,-5.43,;8.31,-4.74,;7.22,-5.83,;.03,.47,;1.37,-.3,;1.37,-1.84,;1.37,-3.38,;-.74,-.87,;-2.28,-.87,;-3.05,.47,;-2.28,1.8,;-.74,1.8,;-4.59,.47,;-5.68,1.56,;-6.77,.47,;-8.31,.47,;-5.68,-.62,)| | ||
| Structure | 
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