| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterol-binding protein 2 |
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| Ligand | BDBM20182 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Sterol-Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 293.15±n/a K |
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| Kd | 17±0.0 nM |
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| Comments | extracted |
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| Citation |  Charman, M; Colbourne, TR; Pietrangelo, A; Kreplak, L; Ridgway, ND Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival. J Biol Chem289:15705-17 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterol-binding protein 2 |
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| Name: | Oxysterol-binding protein 2 |
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| Synonyms: | KIAA1664 | ORP4 | OSBP-related protein 4 (ORP4L) | OSBP2 | OSBP2_HUMAN | OSBPL4 |
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| Type: | Protein |
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| Mol. Mass.: | 101264.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q969R2 |
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| Residue: | 916 |
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| Sequence: | MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEP
ERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFT
KAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALL
PLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDS
CGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKS
ELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLF
RITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSA
PGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGST
GTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPM
PVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFN
PMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISI
MPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPY
SYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTL
SAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTE
KQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGY
WEAKEKQDWHMCPNIF
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| BDBM20182 |
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| n/a |
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| Name | BDBM20182 |
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| Synonyms: | (1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol | 25-Hydroxycholesterol (25OH) | 25-hydroxycholesterol |
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| Type | Small organic molecule |
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| Emp. Form. | C27H46O2 |
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| Mol. Mass. | 402.6529 |
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| SMILES | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@]([H])(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)(C)O |r,t:9| |
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| Structure | 
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