Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM230118 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Jak2 Tyrosine Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1800±n/a nM | ||
| Comments | extracted | ||
| Citation |  Batt, DG; Bertrand, MB; Delucca, G; Galella, MA; Ko, SS; Langevine, CM; Liu, Q; Shi, Q; Srivastava, AS; Tino, JA; Watterson, SH Substituted tetrahydrocarbazole and carbazole carboxamide compounds US Patent US9334290 Publication Date 5/10/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
| ||
| BDBM230118 | |||
| n/a | |||
| Name | BDBM230118 | ||
| Synonyms: | US10106559, Example 47 | US10435415, Example 47 | US9334290, 47 | US9850258, Example 47 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H21Cl2FN4O4 | ||
| Mol. Mass. | 591.417 | ||
| SMILES | CC(C)(O)c1ccc2c(c1)[nH]c1c(cc(Cl)c(-c3cccc(c3Cl)-n3c(=O)[nH]c4c(F)cccc4c3=O)c21)C(N)=O |(-8.37,.74,;-7.03,1.51,;-6.64,.02,;-7.8,2.85,;-5.49,1.51,;-4.59,.27,;-3.06,.43,;-2.43,1.83,;-3.34,3.08,;-4.87,2.92,;-2.43,4.33,;-.97,3.85,;.37,4.62,;1.7,3.85,;1.7,2.31,;3.03,1.54,;.37,1.54,;.37,,;-.97,-.77,;-.97,-2.31,;.37,-3.08,;1.7,-2.31,;1.7,-.77,;3.03,,;3.03,-3.08,;3.03,-4.62,;1.7,-5.39,;4.37,-5.39,;5.7,-4.62,;7.03,-5.39,;7.03,-6.93,;8.37,-4.62,;8.37,-3.08,;7.03,-2.31,;5.7,-3.08,;4.37,-2.31,;4.37,-.77,;-.97,2.31,;.37,6.16,;1.7,6.93,;-.97,6.93,)| | ||
| Structure | 
| ||