Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM230139 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Jak2 Tyrosine Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 550±n/a nM | ||
| Comments | extracted | ||
| Citation |  Batt, DG; Bertrand, MB; Delucca, GV; Galella, MA; Ko, SS; Langevine, CM; Liu, Q; Shi, Q; Srivastava, AS; Tino, JA; Watterson, SH Substituted tetrahydrocarbazole and carbazole carboxamide compounds US Patent US10106559 Publication Date 10/23/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
| ||
| BDBM230139 | |||
| n/a | |||
| Name | BDBM230139 | ||
| Synonyms: | US10106559, Example 70 | US10435415, Example 70 | US9334290, 70 | US9850258, Example 70 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H22F2N4O4 | ||
| Mol. Mass. | 540.5169 | ||
| SMILES | Cc1c(cccc1-n1c(=O)cc2c(F)cccn2c1=O)-c1c(F)cc(C(N)=O)c2[nH]c3cc(CCO)ccc3c12 |(3.63,,;2.3,-.77,;.96,,;-.37,-.77,;-.37,-2.31,;.96,-3.08,;2.3,-2.31,;3.63,-3.08,;3.63,-4.62,;2.3,-5.39,;4.96,-5.39,;6.3,-4.62,;7.63,-5.39,;7.63,-6.93,;8.96,-4.62,;8.96,-3.08,;7.63,-2.31,;6.3,-3.08,;4.96,-2.31,;4.96,-.77,;.96,1.54,;2.3,2.31,;3.63,1.54,;2.3,3.85,;.96,4.62,;.96,6.16,;2.3,6.93,;-.37,6.93,;-.37,3.85,;-1.84,4.33,;-2.74,3.08,;-4.27,2.92,;-4.9,1.51,;-6.39,1.11,;-7.48,2.2,;-8.96,1.8,;-3.99,.27,;-2.46,.43,;-1.84,1.83,;-.37,2.31,)| | ||
| Structure | 
| ||