Reaction Details | |||
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Target | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] | ||
Ligand | BDBM254592 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assay | ||
pH | 7.4±n/a | ||
Temperature | 310.15±n/a K | ||
IC50 | 30±n/a nM | ||
Comments | extracted | ||
Citation | Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martínez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9469597 Publication Date 10/18/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] | |||
Name: | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852] | ||
Synonyms: | GST-Lysine Specific Demethylase-1 (LSD1) | ||
Type: | Enzyme | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Glutathione S-transferase P | ||
Synonyms: | FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST) | ||
Type: | Enzyme | ||
Mol. Mass.: | 23353.53 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P09211 | ||
Residue: | 210 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Lysine-specific histone demethylase 1A [158-852] | ||
Synonyms: | AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine Specific Demethylase-1 (LSD1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 77140.81 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 158-852 | ||
Residue: | 695 | ||
Sequence: |
| ||
BDBM254592 | |||
n/a | |||
Name | BDBM254592 | ||
Synonyms: | US9469597, 51 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H31N5O2S | ||
Mol. Mass. | 477.622 | ||
SMILES | NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(NS(=O)(=O)c2ccc(N)nc2)c1 |r,wU:10.12,wD:8.8,(12.2,3.85,;10.87,3.08,;10.87,1.54,;9.54,.77,;8.2,1.54,;8.2,3.08,;9.54,3.85,;6.87,.77,;5.53,1.54,;4.76,2.87,;3.99,1.54,;2.66,.77,;1.33,1.54,;-.01,.77,;-.01,-.77,;1.33,-1.54,;2.66,-.77,;-1.34,-1.54,;-1.34,-3.08,;-2.67,-3.85,;-4.01,-3.08,;-4.01,-1.54,;-5.34,-.77,;-6.87,-1.64,;-6.1,-2.97,;-7.64,-2.97,;-8.2,-.87,;-8.2,.67,;-9.54,1.44,;-10.87,.67,;-12.2,1.44,;-10.87,-.87,;-9.54,-1.64,;-2.67,-.77,)| | ||
Structure |