| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 4 [648-729,745-1057] |
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| Ligand | BDBM257511 |
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| Substrate/Competitor | US9505736, Boc-Lys(Tfa)-AMC |
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| Meas. Tech. | Biochemical Assay |
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| pH | 8±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 410±n/a nM |
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| Comments | extracted |
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| Citation |  Dominguez, C; Breccia, P; Luckhurst, CA; Bürli, RW; Stott, AJ Histone deacetylase inhibitors and compositions and methods of use thereof US Patent US9505736 Publication Date 11/29/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 4 [648-729,745-1057] |
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| Name: | Histone deacetylase 4 [648-729,745-1057] |
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| Synonyms: | HDAC4 | HDAC4_HUMAN | Histone deacetylase 4 (HDAC4) | KIAA0288 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43928.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | amino acids 648-1057, replacement of amino acids 730-744 with 4 amino acid GSGS |
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| Residue: | 410 |
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| Sequence: | TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKAT
LEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHS
AGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQ
RLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVG
FNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYN
LSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQ
RPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT
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| BDBM257511 |
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| US9505736, Boc-Lys(Tfa)-AMC |
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| Name | BDBM257511 |
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| Synonyms: | US9505736, (1R,2R,3R)-1-Fluoro-2-(4-(5- fluoropyrimidin-2-yl)phenyl)-N-hydroxy-3- phenylcyclopropanecarboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15F2N3O2 |
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| Mol. Mass. | 367.3488 |
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| SMILES | ONC(=O)[C@@]1(F)[C@H]([C@@H]1c1ccc(cc1)-c1ncc(F)cn1)c1ccccc1 |r| |
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| Structure | 
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