| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
|---|
| Ligand | BDBM328280 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | enzyme-linked immunosorbent assay |
|---|
| EC50 | <500±n/a nM |
|---|
| Citation |  Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y AMPK-activating heterocyclic compounds and methods for using the same US Patent US10377742 Publication Date 8/13/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
|---|
| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
|---|
| Synonyms: | AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62331.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P54646 |
|---|
| Residue: | 552 |
|---|
| Sequence: | MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
|
|
|
|---|
| BDBM328280 |
|---|
| n/a |
|---|
| Name | BDBM328280 |
|---|
| Synonyms: | 6-(4-(4-cyanophenoxy) piperidine-1-carbonyl)- N-(1-(4- cyanophenyl)piperidin- 4-yl)nicotinamide | US10377742, Compound 418 | US9663496, Compound 418 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H30N6O3 |
|---|
| Mol. Mass. | 534.6083 |
|---|
| SMILES | O=C(NC1CCN(CC1)c1ccc(cc1)C#N)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
