Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [342-460] | ||
| Ligand | BDBM318613 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | AlphaScreen Assay A2 | ||
| IC50 | <100±n/a nM | ||
| Citation |  Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent US10464947 Publication Date 11/5/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [342-460] | |||
| Name: | Bromodomain-containing protein 4 [342-460] | ||
| Synonyms: | BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13783.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | a.a. 342-460 (BRD4-BD2) | ||
| Residue: | 119 | ||
| Sequence: |
| ||
| BDBM318613 | |||
| n/a | |||
| Name | BDBM318613 | ||
| Synonyms: | 7-(3,5-Dimethylisoxazol-4-yl)-2-methyl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine | US10464947, Example 154 | US11498926, Example 154 | US9624241, Example 154 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H18N4O2 | ||
| Mol. Mass. | 346.3825 | ||
| SMILES | Cc1noc(C)c1-c1ccc2nc(C)n3[C@H](COc1c23)c1ccccn1 |r,wD:15.23,(-3.44,-2.04,;-2.67,-3.37,;-3.57,-4.62,;-2.67,-5.87,;-1.2,-5.39,;.13,-6.16,;-1.2,-3.85,;.13,-3.08,;1.47,-3.85,;2.8,-3.08,;2.8,-1.54,;3.57,-.21,;2.8,1.13,;3.57,2.46,;1.47,.77,;.13,1.54,;-1.2,.77,;-1.2,-.77,;.13,-1.54,;1.47,-.77,;.13,3.08,;1.47,3.85,;1.47,5.39,;.13,6.16,;-1.2,5.39,;-1.2,3.85,)| | ||
| Structure | 
| ||