| Reaction Details |
|---|
 | Report a problem with these data |
| Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Ligand | BDBM429782 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | hADAMTS-5 assay |
|---|
| IC50 | >100±n/a nM |
|---|
| Citation |  Labéguère, FG; Heng, R; De Ceuninck, FA; Alvey, LJ; Amantini, D; Brebion, FL; Deprez, PM; Gosmini, RL; Jary, HM; Peixoto, C; Pop-Botez, IE; Varin, ML 5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis US Patent US10550100 Publication Date 2/4/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) | ADAMTS11 | ADAMTS5 | ADMP2 | ATS5_HUMAN | Aggrecanase-2 | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 101769.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UNA0 |
|---|
| Residue: | 930 |
|---|
| Sequence: | MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
|
|
|
|---|
| BDBM429782 |
|---|
| n/a |
|---|
| Name | BDBM429782 |
|---|
| Synonyms: | (5R)-5-[3-[4- (4-chloro-3- ethyl-5- methoxy- phenyl)-1- piperidyl]-3- oxo-propyl] imidazolidine- 2,4-dione | US10550100, Compound 106 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H30ClN3O5 |
|---|
| Mol. Mass. | 451.944 |
|---|
| SMILES | CCc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CC[C@@]1(COC)NC(=O)NC1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
