| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
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| Ligand | BDBM430125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Ca2+ Flux Assay |
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| IC50 | 263±n/a nM |
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| Citation |  Conn, PJ; Lindsley, CW; Emmitte, KA; Felts, AS; Bollinger, KA 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators US Patent US10538491 Publication Date 1/21/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 2 |
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| Name: | Metabotropic glutamate receptor 2 |
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| Synonyms: | GRM2_RAT | Gprc1b | Grm2 | Mglur2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95786.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105034 |
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| Residue: | 872 |
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| Sequence: | MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGAL
ESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAP
RASANLGQGSGSQFVPTVCNGREVVDSTTSSL
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| BDBM430125 |
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| n/a |
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| Name | BDBM430125 |
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| Synonyms: | 4-(4-fluorophenyl)-5-( thiazol-5-ylmethoxy)picolinamide | US10538491, Compound 51 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12FN3O2S |
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| Mol. Mass. | 329.349 |
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| SMILES | NC(=O)c1cc(c(OCc2cncs2)cn1)-c1ccc(F)cc1 |
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| Structure | 
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