Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257064 (CHEMBL2386850) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGlu5 receptor expressed in HEK293A cell membranes after 1 hr by scintillatio... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5 | Bioorg Med Chem Lett 19: 6623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.024 BindingDB Entry DOI: 10.7270/Q2TX3FHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50442525 (CHEMBL2440659 | US8796295, Table 2: Compound: 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor allosteric binding site (unknown origin) | Bioorg Med Chem Lett 23: 5779-85 (2013) Article DOI: 10.1016/j.bmcl.2013.09.001 BindingDB Entry DOI: 10.7270/Q2X92CSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50047700 (CHEMBL3314850) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]methoxyPEPy from rat mGlu5 expressed in HEK293A cells after 1 hr by scintillation counting method | Bioorg Med Chem Lett 24: 3307-14 (2014) Article DOI: 10.1016/j.bmcl.2014.06.003 BindingDB Entry DOI: 10.7270/Q2ZW1NJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M5 (RAT) | BDBM50605085 (CHEMBL5204021) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00192 BindingDB Entry DOI: 10.7270/Q23N27HG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50323286 (3-cyano-5-fluoro-N-m-tolylbenzamide | CHEMBL120920...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation counting | Bioorg Med Chem Lett 20: 4390-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.064 BindingDB Entry DOI: 10.7270/Q2V9888D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50323308 (3-cyano-5-fluoro-N-(4-methylthiazol-2-yl)benzamide...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 102 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation counting | Bioorg Med Chem Lett 20: 4390-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.064 BindingDB Entry DOI: 10.7270/Q2V9888D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50311887 (6-bromo-N-(3-chlorophenyl)quinazolin-4-amine | CHE...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 116 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5 | Bioorg Med Chem Lett 19: 6623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.024 BindingDB Entry DOI: 10.7270/Q2TX3FHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50258619 (3-Cyano-5-fluoro-N-(6-methylpyridin-2-yl)-benzamid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation counting | Bioorg Med Chem Lett 20: 4390-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.064 BindingDB Entry DOI: 10.7270/Q2V9888D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50323289 (CHEMBL1209202 | N-(3-chlorophenyl)-3-cyano-5-fluor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 206 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation counting | Bioorg Med Chem Lett 20: 4390-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.064 BindingDB Entry DOI: 10.7270/Q2V9888D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257064 (CHEMBL2386850) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50311876 (CHEMBL1075626 | N-(3-bromophenyl)-6-chloroquinazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 249 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5 | Bioorg Med Chem Lett 19: 6623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.024 BindingDB Entry DOI: 10.7270/Q2TX3FHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257087 (CHEMBL4102569) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 388 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGlu5 receptor expressed in HEK293A cell membranes after 1 hr by scintillatio... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50311858 (CHEMBL1076333 | N-(3-bromophenyl)-6-fluoroquinazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 736 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5 | Bioorg Med Chem Lett 19: 6623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.024 BindingDB Entry DOI: 10.7270/Q2TX3FHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Binding affinity to wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrate | ACS Med Chem Lett 4: 486-490 (2013) Article DOI: 10.1021/ml400066a BindingDB Entry DOI: 10.7270/Q28D005G | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human)) | BDBM50426242 (CHEMBL2312346) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00192 BindingDB Entry DOI: 10.7270/Q23N27HG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50491628 (CHEMBL2386352) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Binding affinity to wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrate | ACS Med Chem Lett 4: 486-490 (2013) Article DOI: 10.1021/ml400066a BindingDB Entry DOI: 10.7270/Q28D005G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM50426242 (CHEMBL2312346) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00192 BindingDB Entry DOI: 10.7270/Q23N27HG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human)) | BDBM50426242 (CHEMBL2312346) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00192 BindingDB Entry DOI: 10.7270/Q23N27HG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human)) | BDBM50426242 (CHEMBL2312346) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00192 BindingDB Entry DOI: 10.7270/Q23N27HG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human)) | BDBM50426242 (CHEMBL2312346) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00192 BindingDB Entry DOI: 10.7270/Q23N27HG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM22165 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA. Curated by ChEMBL | Assay Description Displacement of [125I]RTI-55 from recombinant human DAT expressed in CHOK1 cells after 3 hrs by scintillation counting method | Bioorg Med Chem Lett 27: 4858-4866 (2017) Article DOI: 10.1016/j.bmcl.2017.09.042 BindingDB Entry DOI: 10.7270/Q2V1278Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50560457 (CHEMBL4790396) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (RAT) | BDBM50605085 (CHEMBL5204021) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00192 BindingDB Entry DOI: 10.7270/Q23N27HG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50447893 (CHEMBL3114792) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptake | Bioorg Med Chem Lett 24: 1067-70 (2014) Article DOI: 10.1016/j.bmcl.2014.01.013 BindingDB Entry DOI: 10.7270/Q2K64KK4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257058 (CHEMBL2386849) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257058 (CHEMBL2386849) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257041 (CHEMBL4077672) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257041 (CHEMBL4077672) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50447910 (CHEMBL3114969) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptake | Bioorg Med Chem Lett 24: 1067-70 (2014) Article DOI: 10.1016/j.bmcl.2014.01.013 BindingDB Entry DOI: 10.7270/Q2K64KK4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50560480 (CHEMBL4779300) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM50560467 (CHEMBL4788859) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM50560477 (CHEMBL4742906) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM50560479 (CHEMBL4778971) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50560477 (CHEMBL4742906) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50560478 (CHEMBL4790557) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50560479 (CHEMBL4778971) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM50560468 (CHEMBL4786529) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50560481 (CHEMBL4746124) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM50560477 (CHEMBL4742906) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK1 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM50560466 (CHEMBL4740381) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50447890 (CHEMBL3114971) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptake | Bioorg Med Chem Lett 24: 1067-70 (2014) Article DOI: 10.1016/j.bmcl.2014.01.013 BindingDB Entry DOI: 10.7270/Q2K64KK4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50560482 (CHEMBL4753476) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50560472 (CHEMBL4741939) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127418 BindingDB Entry DOI: 10.7270/Q2WW7NDJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257059 (CHEMBL4082854) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257059 (CHEMBL4082854) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM128279 (US8796295, Table 2: Compound: 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description The utility of the compounds in accordance with the present invention as negative allosteric modulators of metabotropic glutamate receptor activity, ... | US Patent US8796295 (2014) BindingDB Entry DOI: 10.7270/Q2542M8B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257080 (CHEMBL4096818) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50257080 (CHEMBL4096818) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Curated by ChEMBL | Assay Description Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei... | J Med Chem 60: 5072-5085 (2017) Article DOI: 10.1021/acs.jmedchem.7b00410 BindingDB Entry DOI: 10.7270/Q2JH3PM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50457526 (CHEMBL4213773) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Negative allosteric modulator activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of EC80 glutamate-induced Ca2+ mobiliz... | Bioorg Med Chem Lett 28: 1679-1685 (2018) Article DOI: 10.1016/j.bmcl.2018.04.053 BindingDB Entry DOI: 10.7270/Q2RV0R96 | |||||||||||
More data for this Ligand-Target Pair |
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