| Reaction Details |
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 | Report a problem with these data |
| Target | OTU domain-containing protein 7B |
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| Ligand | BDBM443320 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | 550±n/a nM |
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| Citation |  Kemp, MI; Stockley, ML; Woodrow, MD; Jones, A Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors US Patent US10654853 Publication Date 5/19/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| OTU domain-containing protein 7B |
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| Name: | OTU domain-containing protein 7B |
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| Synonyms: | Cellular zinc finger anti-NF-kappa-B protein | Cezanne | OTU7B_HUMAN | OTUD7B | ZA20D1 | Zinc finger A20 domain-containing protein 1 | Zinc finger protein Cezanne |
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| Type: | Protein |
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| Mol. Mass.: | 92527.32 |
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| Organism: | Human |
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| Description: | Q6GQQ9 |
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| Residue: | 843 |
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| Sequence: | MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
KLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNE
GGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLG
GSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILR
TAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGG
PPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPC
VGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYR
EPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLV
HRF
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| BDBM443320 |
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| n/a |
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| Name | BDBM443320 |
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| Synonyms: | 6'-(4-(Benzyloxy)phenyl)-2'-oxo-1',4'- dihydro-2'H-spiro[pyrrolidine-3,3'- quinoline]-1-carbonitrile | US10654853, Example 93 | US11236092, Example 93 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23N3O2 |
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| Mol. Mass. | 409.4797 |
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| SMILES | O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1ccc(OCc2ccccc2)cc1 |
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| Structure | 
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