Reaction Details |
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Target | Prostaglandin E synthase |
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Ligand | BDBM451590 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Activity Assay |
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IC50 | 32.0±n/a nM |
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Citation | Okada, M; Nakano, Y; Nose, T; Nishimoto, T; Maeda, S Pyrimidine derivative US Patent US10710967 Publication Date 7/14/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin E synthase |
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Name: | Prostaglandin E synthase |
Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
Type: | Protein |
Mol. Mass.: | 17112.22 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 152 |
Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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BDBM451590 |
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n/a |
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Name | BDBM451590 |
Synonyms: | US10710967, Example 190 |
Type | Small organic molecule |
Emp. Form. | C26H29ClN4O4 |
Mol. Mass. | 496.986 |
SMILES | CCCC(=O)NCc1ccc(Cl)c(c1)-c1nc(cc(=O)[nH]1)-c1ccc(OCC2CCOCC2)nc1 |
Structure |
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