Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase receptor R3 [166-493]

Ligand

BDBM451847

Substrate/Competitor

n/a

Meas. Tech.

Caliper Assay

IC50

210±n/a nM

Citation

Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10710980 Publication Date 7/14/2020

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase receptor R3 [166-493]

Name:

Serine/threonine-protein kinase receptor R3 [166-493]

Synonyms:

ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK1)(aa 166-493)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

36974.75

Organism:

Homo sapiens (Human)

Description:

aa 166-493

Residue:

328

Sequence:

ASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGES
VAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSL
YDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCC
IADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVL
WEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLA
QMMRECWYPNPSARLTALRIKKTLQKIS

BDBM451847

n/a

Name

BDBM451847

Synonyms:

US10710980, Example 75 | US10947218, Example 75

Type

Small organic molecule

Emp. Form.

C26H34N4O3

Mol. Mass.

450.5732

SMILES

COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)|

Structure