| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase EZH2 [A677G] |
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| Ligand | BDBM50287072 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| IC50 | 10.00±n/a nM |
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| Citation |  Lu, B; Shen, X; He, M; Liu, D; Zhang, M Benzofuran derivative, preparation method thereof and use thereof in medicine US Patent US10759787 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase EZH2 [A677G] |
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| Name: | Histone-lysine N-methyltransferase EZH2 [A677G] |
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| Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A677G) | KMT6 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 85485.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa A677G |
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| Residue: | 747 |
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| Sequence: | MMGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQE
WKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQN
FMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALG
QYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEE
LKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPF
HATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLP
NNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIK
MKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAP
APAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIA
QNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNV
SCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYD
KYMCSFLFNLNNDFVVDGTRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTG
EELFFDYRYSQADALKYVGIEREMEIP
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| BDBM50287072 |
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| n/a |
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| Name | BDBM50287072 |
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| Synonyms: | CHEMBL4159112 | US10759787, Example 12 | US11059811, Example 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H45N5O5 |
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| Mol. Mass. | 579.7302 |
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| SMILES | CCN(C1CCOCC1)c1cc2oc(CN3CCN(C)CC3)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC |
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| Structure | 
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