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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM221686 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Amplified Luminescence Proximity Homogeneous Assay | ||
| IC50 | 0.700±n/a nM | ||
| Citation |  Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Compounds and compositions as protein kinase inhibitors US Patent US9593099 Publication Date 3/14/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM221686 | |||
| n/a | |||
| Name | BDBM221686 | ||
| Synonyms: | US10568884, Cpd 7 | US9314464, 7 | US9593100, Compound 7 | USRE49556, Compound 7 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H31F2N7O4S | ||
| Mol. Mass. | 551.609 | ||
| SMILES | CCCS(=O)(=O)Nc1ccc(F)c(-c2nn(cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C(C)C)c1F |r,wD:25.26,(6.55,-9.31,;6.95,-7.82,;5.86,-6.73,;6.26,-5.24,;4.77,-4.85,;7.74,-5.64,;6.66,-3.76,;5.57,-2.67,;5.97,-1.18,;4.88,-.09,;3.39,-.49,;2.3,.6,;2.99,-1.98,;1.5,-2.38,;1.03,-3.84,;-.51,-3.84,;-.99,-2.38,;.26,-1.47,;.26,.07,;1.59,.84,;1.59,2.38,;.26,3.15,;-1.08,2.38,;-2.41,3.15,;-2.41,4.69,;-3.74,5.46,;-5.08,4.69,;-3.74,7,;-5.08,7.77,;-5.08,9.31,;-6.41,7,;-7.74,7.77,;-1.08,.84,;-1.28,-5.17,;-.51,-6.51,;-2.82,-5.17,;4.08,-3.07,;3.68,-4.55,)| | ||
| Structure | 
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