Reaction Details |
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Target | Polymerase acidic protein |
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Ligand | BDBM474363 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Endonuclease Inhibition Assay (PA FP Assay) |
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IC50 | 100.0±n/a nM |
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Citation | Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent US10858366 Publication Date 12/8/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Polymerase acidic protein |
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Name: | Polymerase acidic protein |
Synonyms: | PA | PA_I75A3 | RNA-directed RNA polymerase subunit P2 |
Type: | Protein |
Mol. Mass.: | 82806.72 |
Organism: | n/a |
Description: | P31343 |
Residue: | 716 |
Sequence: | MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSENTHIHIFSFTGEGMATKADYTLDEESRARIKTRLFTIRQ
EMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNG
CIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPYIVKPHERGINSNYLLSWKQVLAELQDIENEEKIPRTKNM
KKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDS
IWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
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BDBM474363 |
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n/a |
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Name | BDBM474363 |
Synonyms: | (S)-6-benzhydryl-11-hydroxy-3- (methoxymethyl)-5,6-dihydro-10H- imidazo[1,2-a]pyrido[2,1-c]pyrazin-10-one | US10858366, Example 56 | US11453677, Example 56 |
Type | Small organic molecule |
Emp. Form. | C25H23N3O3 |
Mol. Mass. | 413.4684 |
SMILES | COCc1cnc2-c3c(O)c(=O)ccn3[C@H](Cn12)C(c1ccccc1)c1ccccc1 |r| |
Structure |
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