Reaction Details |
| Report a problem with these data |
Target | Ubiquitin-like modifier-activating enzyme ATG7 |
---|
Ligand | BDBM476054 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Assay |
---|
IC50 | 35±n/a nM |
---|
Citation | Adhikari, S; Calderwood, EF; England, DB; Gould, AE; Harrison, SJ; Huang, S; Ma, L ATG7 inhibitors and the uses thereof US Patent US10865208 Publication Date 12/15/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ubiquitin-like modifier-activating enzyme ATG7 |
---|
Name: | Ubiquitin-like modifier-activating enzyme ATG7 |
Synonyms: | APG7-like | APG7L | ATG12-activating enzyme E1 ATG7 | ATG7 | ATG7_HUMAN | Autophagy-related protein 7 | Ubiquitin-activating enzyme E1-like protein | hAGP7 |
Type: | PROTEIN |
Mol. Mass.: | 77955.74 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_939703 |
Residue: | 703 |
Sequence: | MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLP
ARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGT
ALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEAL
ECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQY
PGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPK
AVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLL
LGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADR
LQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRES
RWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLF
ANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEG
GYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYERE
GFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
|
|
|
BDBM476054 |
---|
n/a |
---|
Name | BDBM476054 |
Synonyms: | US10865208, Compound I-111 | [(2R,3R,4S,5R)-5-{4-amino-3-[(5-nitropyridin-2-yl)sulfanyl]-1H-pyrazolo[3,4- d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate |
Type | Small organic molecule |
Emp. Form. | C15H15FN8O7S2 |
Mol. Mass. | 502.457 |
SMILES | Nc1ncnc2n(nc(Sc3ccc(cn3)[N+]([O-])=O)c12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@@H]1F |r| |
Structure |
|