Reaction Details |
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Target | Ubiquitin-like modifier-activating enzyme ATG7 |
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Ligand | BDBM476059 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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IC50 | 35±n/a nM |
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Citation | Adhikari, S; Calderwood, EF; England, DB; Gould, AE; Harrison, SJ; Huang, S; Ma, L ATG7 inhibitors and the uses thereof US Patent US10865208 Publication Date 12/15/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin-like modifier-activating enzyme ATG7 |
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Name: | Ubiquitin-like modifier-activating enzyme ATG7 |
Synonyms: | APG7-like | APG7L | ATG12-activating enzyme E1 ATG7 | ATG7 | ATG7_HUMAN | Autophagy-related protein 7 | Ubiquitin-activating enzyme E1-like protein | hAGP7 |
Type: | PROTEIN |
Mol. Mass.: | 77955.74 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_939703 |
Residue: | 703 |
Sequence: | MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLP
ARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGT
ALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEAL
ECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQY
PGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPK
AVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLL
LGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADR
LQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRES
RWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLF
ANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEG
GYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYERE
GFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
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BDBM476059 |
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n/a |
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Name | BDBM476059 |
Synonyms: | US10865208, Compound I-116 | [(2R,3R,4S,5R)-5-{4-amino-3-[(3-fluorophenyl)sulfanyl]-1H-pyrazolo[3,4- d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate |
Type | Small organic molecule |
Emp. Form. | C16H16F2N6O5S2 |
Mol. Mass. | 474.462 |
SMILES | Nc1ncnc2n(nc(Sc3cccc(F)c3)c12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@@H]1F |r| |
Structure |
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