| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin-like modifier-activating enzyme ATG7 |
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| Ligand | BDBM476060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 35±n/a nM |
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| Citation |  Adhikari, S; Calderwood, EF; England, DB; Gould, AE; Harrison, SJ; Huang, S; Ma, L ATG7 inhibitors and the uses thereof US Patent US10865208 Publication Date 12/15/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin-like modifier-activating enzyme ATG7 |
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| Name: | Ubiquitin-like modifier-activating enzyme ATG7 |
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| Synonyms: | APG7-like | APG7L | ATG12-activating enzyme E1 ATG7 | ATG7 | ATG7_HUMAN | Autophagy-related protein 7 | Ubiquitin-activating enzyme E1-like protein | hAGP7 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77955.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_939703 |
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| Residue: | 703 |
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| Sequence: | MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLP
ARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGT
ALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEAL
ECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQY
PGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPK
AVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLL
LGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADR
LQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRES
RWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLF
ANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEG
GYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYERE
GFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
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| BDBM476060 |
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| n/a |
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| Name | BDBM476060 |
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| Synonyms: | US10865208, Compound I-117 | [(2R,3R,4S,5R)-5-(4-amino-3-{[4-(trifluoromethyl)pyridin-2-yl]sulfanyl}-1H- pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15F4N7O5S2 |
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| Mol. Mass. | 525.458 |
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| SMILES | Nc1ncnc2n(nc(Sc3cc(ccn3)C(F)(F)F)c12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@@H]1F |r| |
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| Structure | 
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