Reaction Details |
| Report a problem with these data |
Target | SH2B adapter protein 2 |
---|
Ligand | BDBM485013 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Allosteric Inhibition Assay |
---|
IC50 | <50±n/a nM |
---|
Citation | Taylor, AM; Lescarbeau, A; Kelley, EH; Shortsleeves, KC; Walters, WP; Murcko, MA; Giordanetto, F; Therrien, E SHP2 phosphatase inhibitors and methods of use thereof US Patent US10934302 Publication Date 3/2/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
SH2B adapter protein 2 |
---|
Name: | SH2B adapter protein 2 |
Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
Type: | Protein |
Mol. Mass.: | 67733.52 |
Organism: | Human |
Description: | O14492 |
Residue: | 632 |
Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
|
|
|
BDBM485013 |
---|
n/a |
---|
Name | BDBM485013 |
Synonyms: | US10934302, Example 264 |
Type | Small organic molecule |
Emp. Form. | C23H30N4S |
Mol. Mass. | 394.576 |
SMILES | N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc(SCC2CCCC2)cn1 |r| |
Structure |
|