Reaction Details | |||
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Target | Activin receptor type-1 [172-499,R206H] | ||
Ligand | BDBM451785 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Caliper Assay | ||
IC50 | 14.0±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Activin receptor type-1 [172-499,R206H] | |||
Name: | Activin receptor type-1 [172-499,R206H] | ||
Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ALK2 FOP) (R206H aa 172-499) | Activin receptor type-1 (ALK2)(FOP)(R206H) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 37120.09 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 172-499 | ||
Residue: | 328 | ||
Sequence: |
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BDBM451785 | |||
n/a | |||
Name | BDBM451785 | ||
Synonyms: | US10710980, Example 17 | US10947218, Example 17 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H31F3N4O2 | ||
Mol. Mass. | 488.5451 | ||
SMILES | Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC(F)(F)F)C2 |r,wU:25.27,10.10,wD:23.25,13.14,(-4.76,5.73,;-3.43,4.96,;-2.1,5.73,;-.76,4.96,;-.76,3.42,;-2.1,2.65,;-3.43,3.42,;-4.76,2.65,;-6.1,3.42,;-4.76,1.11,;-6.25,.72,;-6.65,-.77,;-8.14,-1.17,;-9.23,-.08,;-10.72,-.48,;-8.83,1.41,;-7.34,1.81,;.57,2.65,;.57,1.11,;1.9,.34,;3.24,1.11,;3.24,2.65,;1.9,3.42,;4.57,.34,;4.73,1.88,;5.98,.97,;7.01,-.17,;6.24,-1.51,;6.86,-2.91,;8.41,-2.91,;9.18,-4.25,;10.72,-4.25,;8.41,-5.58,;9.57,-5.73,;4.73,-1.19,)| | ||
Structure | ![]() |