| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B |
|---|
| Ligand | BDBM451789 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Caliper Assay |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bone morphogenetic protein receptor type-1B |
|---|
| Name: | Bone morphogenetic protein receptor type-1B |
|---|
| Synonyms: | ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56939.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00238 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
|
|
|
|---|
| BDBM451789 |
|---|
| n/a |
|---|
| Name | BDBM451789 |
|---|
| Synonyms: | US10710980, Example 21 | US10947218, Example 21 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H35FN4O3 |
|---|
| Mol. Mass. | 494.6009 |
|---|
| SMILES | Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
