| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 30 |
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| Ligand | BDBM498844 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | 550±n/a nM |
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| Citation |  Stockley, ML; Kemp, MI; Madin, A; Woodrow, MD; Jones, A Cyanopyrrolidine derivatives with activity as inhibitors of USP30 US Patent US11014912 Publication Date 5/25/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 30 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 30 |
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| Synonyms: | Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30 |
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| Type: | Protein |
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| Mol. Mass.: | 58522.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q70CQ3 |
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| Residue: | 517 |
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| Sequence: | MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK
KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL
LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ
PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ
SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK
VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG
HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP
FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT
VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
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| BDBM498844 |
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| n/a |
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| Name | BDBM498844 |
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| Synonyms: | N-(4-Chloro-3- (trifluoromethyl)phenyl)-2-(1- cyanopyrrolidin-3- ylidene)acetamide | US11014912, Example 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11ClF3N3O |
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| Mol. Mass. | 329.705 |
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| SMILES | FC(F)(F)c1cc(NC(=O)C=C2CCN(C2)C#N)ccc1Cl |w:10.9| |
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| Structure | 
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