Reaction Details |
| Report a problem with these data |
Target | Serine protease HTRA1 |
---|
Ligand | BDBM499311 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
IC50 | 0.400±n/a nM |
---|
Citation | Hornsperger, B; Iacone, R; Maerki, HP; Mohr, P; Reutlinger, M Trifluoromethylpropanamide derivatives as HTRA1 inhibitors US Patent US11014963 Publication Date 5/25/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine protease HTRA1 |
---|
Name: | Serine protease HTRA1 |
Synonyms: | HTRA | HTRA1 | HTRA1_HUMAN | PRSS11 |
Type: | Protein |
Mol. Mass.: | 51293.95 |
Organism: | Homo sapiens (Human) |
Description: | Q92743 |
Residue: | 480 |
Sequence: | MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG
SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA
PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA
KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT
QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI
KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD
TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
|
|
|
BDBM499311 |
---|
n/a |
---|
Name | BDBM499311 |
Synonyms: | US11014963, Example 216 |
Type | Small organic molecule |
Emp. Form. | C39H37ClF5N5O6 |
Mol. Mass. | 802.186 |
SMILES | COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1ccc(CNC(=O)c2ccccn2)cc1)NC(=O)C(F)(F)c1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F |r| |
Structure |
|