| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM287643 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 5500±n/a nM |
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| Citation |  Sparks, S; Yates, CM; Shaver, SR; Hoekstra, WJ Metalloenzyme inhibitor compounds US Patent US11040034 Publication Date 6/22/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
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| Type: | Enzyme |
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| Mol. Mass.: | 57591.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15538 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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| BDBM287643 |
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| n/a |
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| Name | BDBM287643 |
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| Synonyms: | US10085984, Example 21 | US11040034, Ex. No. 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13F2N5 |
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| Mol. Mass. | 301.294 |
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| SMILES | CNc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1 |
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| Structure | 
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