| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
|---|
| Ligand | BDBM287644 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| IC50 | 50±n/a nM |
|---|
| Citation |  Sparks, S; Yates, CM; Shaver, SR; Hoekstra, WJ Metalloenzyme inhibitor compounds US Patent US11040034 Publication Date 6/22/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B2, mitochondrial |
|---|
| Name: | Cytochrome P450 11B2, mitochondrial |
|---|
| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57582.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P19099 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
|
|
|
|---|
| BDBM287644 |
|---|
| n/a |
|---|
| Name | BDBM287644 |
|---|
| Synonyms: | US10085984, Example 22 | US11040034, Ex. No. 22 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H9ClF2N4 |
|---|
| Mol. Mass. | 306.698 |
|---|
| SMILES | Fc1cc2nc(-c3cnnc(Cl)c3)n(C3CC3)c2cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
