| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM504571 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| IC50 | 64.0±n/a nM |
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| Citation |  Walji, A; Berger, R; Stump, CA; Schlegel, KS; Mulhearn, JJ; Greshock, TJ; Wang, D; Fraley, ME; Jones, KG 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors US Patent US11066396 Publication Date 7/20/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM504571 |
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| n/a |
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| Name | BDBM504571 |
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| Synonyms: | (S)-5-(3-(Pyridin-2-yl)-1,2,4-oxadiazol-5-yl)-4-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)morpholin-3-one | US11066396, Example 34 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H13F3N6O4 |
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| Mol. Mass. | 458.3502 |
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| SMILES | FC(F)(F)c1nc(no1)-c1ccc(cc1)N1[C@@H](COCC1=O)c1nc(no1)-c1ccccn1 |r| |
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| Structure | 
|
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