| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 3 |
|---|
| Ligand | BDBM507122 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FGFR3 Enzyme Inhibition |
|---|
| Ki | 7.90±n/a nM |
|---|
| Citation |  Walters, I; Birch, L; Hill-Cousins, J; Collingwood, SP; Stevenson, CS Indolinones compounds and their use in the treatment of fibrotic diseases US Patent US11046672 Publication Date 6/29/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 3 |
|---|
| Name: | Fibroblast growth factor receptor 3 |
|---|
| Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 87699.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22607 |
|---|
| Residue: | 806 |
|---|
| Sequence: | MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
|
|
|
|---|
| BDBM507122 |
|---|
| n/a |
|---|
| Name | BDBM507122 |
|---|
| Synonyms: | US11046672, Example 73 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H38N6O6 |
|---|
| Mol. Mass. | 626.7021 |
|---|
| SMILES | CNC(=O)CN1CCN(CCONC(=O)c2ccc(N\C(=C3/C(=O)Nc4cc(C(=O)OC)c(C)cc34)c3ccccc3)cc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
