| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 |
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| Ligand | BDBM50464639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibitory Activity Assay |
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| IC50 | 245±n/a nM |
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| Citation |  Yin, L; Liu, W; Li, H; Zhu, D Protein kinase inhibitors, preparation method and medical use thereof US Patent US11091476 Publication Date 8/17/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 |
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| Name: | Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 |
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| Synonyms: | CDK9/D3 | Cyclin-dependent kinase 1/ G1/S-specific cyclin-D3 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
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| Synonyms: | CCND3 | CCND3_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 32521.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30281 |
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| Residue: | 292 |
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| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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| BDBM50464639 |
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| n/a |
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| Name | BDBM50464639 |
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| Synonyms: | CHEMBL4291740 | US11091476, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25F2N7 |
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| Mol. Mass. | 449.499 |
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| SMILES | CC1=Nc2c(cc(cc2F)-c2nc(Nc3ccc(cn3)N3CCNCC3)ncc2F)C1(C)C |t:1| |
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| Structure | 
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