| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 |
|---|
| Ligand | BDBM50464615 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Inhibitory Activity Assay |
|---|
| IC50 | 50.0±n/a nM |
|---|
| Citation |  Yin, L; Liu, W; Li, H; Zhu, D Protein kinase inhibitors, preparation method and medical use thereof US Patent US11091476 Publication Date 8/17/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 |
|---|
| Name: | Cyclin-dependent kinase 1/G1/S-specific cyclin-D3 |
|---|
| Synonyms: | CDK9/D3 | Cyclin-dependent kinase 1/ G1/S-specific cyclin-D3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 1 |
|---|
| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 34101.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06493 |
|---|
| Residue: | 297 |
|---|
| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
|
|
|
|---|
| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
|---|
| Synonyms: | CCND3 | CCND3_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32521.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30281 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
|
|
|
|---|
| BDBM50464615 |
|---|
| n/a |
|---|
| Name | BDBM50464615 |
|---|
| Synonyms: | CHEMBL4289350 | US11091476, Example 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H33F2N7 |
|---|
| Mol. Mass. | 517.616 |
|---|
| SMILES | CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc4c(N=C(C)C44CCCC4)c(F)c3)nc2)CC1 |t:24| |
|---|
| Structure | 
|
|---|
Search and Browse
