Reaction Details |
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Target | Oxidized low-density lipoprotein receptor 1 |
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Ligand | BDBM454238 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | >300±n/a nM |
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Citation | Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Zhou, W; Robertson, AD Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof US Patent US11098045 Publication Date 8/24/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Oxidized low-density lipoprotein receptor 1 |
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Name: | Oxidized low-density lipoprotein receptor 1 |
Synonyms: | LOX-1 | LOX1 | Lectin-like oxLDL receptor 1 | Lectin-like oxidized LDL receptor 1 | Lectin-type oxidized LDL receptor 1 | OLR1 | OLR1_BOVIN | Ox-LDL receptor 1 | bLOX-1 |
Type: | Protein |
Mol. Mass.: | 30894.65 |
Organism: | Bovine |
Description: | P79391 |
Residue: | 270 |
Sequence: | MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVS
DLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELH
RQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINS
TDELEFIQQMIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCA
YIQRGTVFAENCILTAFSICQKKANLLRAQ
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BDBM454238 |
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n/a |
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Name | BDBM454238 |
Synonyms: | (Z)-1-(4-amino-2-fluorobut-2-en-l-yl)-3- (3-(tert-butyl)phenyl)-2-methyl-1H- indole-5-carboxylic acid | US10717733, Compound 31 | US11098045, Compound 31 |
Type | Small organic molecule |
Emp. Form. | C24H27FN2O2 |
Mol. Mass. | 394.4818 |
SMILES | Cc1c(-c2cccc(c2)C(C)(C)C)c2cc(ccc2n1C\C(F)=C\CN)C(O)=O |
Structure |
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