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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM515806 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Verification on Inhibitory Activities of TAM Receptor Inhibiting Compounds on Tyro 3, Axl, and Mer | ||
| IC50 | 0.900±n/a nM | ||
| Citation |  Cho, SY; Lee, CH; Min, YK; Hwang, JY Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient US Patent US11053225 Publication Date 7/6/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM515806 | |||
| n/a | |||
| Name | BDBM515806 | ||
| Synonyms: | US11053225, Compound 115 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24F5N7O2 | ||
| Mol. Mass. | 525.4744 | ||
| SMILES | OCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1NC1CC[C@@H](CC1)NC(=O)C(F)(F)F |r,wD:27.33,(3.3,-10.38,;4.21,-9.13,;3.58,-7.72,;4.49,-6.48,;4.01,-5.01,;5.26,-4.11,;6.5,-5.01,;6.03,-6.48,;5.26,-2.57,;6.59,-1.8,;6.59,-.26,;5.26,.51,;5.26,2.05,;3.92,2.82,;2.59,2.05,;1.26,2.82,;-.08,2.05,;1.26,4.36,;2.59,5.13,;2.59,6.67,;3.92,4.36,;3.92,-.26,;3.92,-1.8,;2.59,-2.57,;1.26,-1.8,;-.08,-2.57,;-1.41,-1.8,;-1.41,-.26,;-.08,.51,;1.26,-.26,;-2.74,.51,;-2.74,2.05,;-1.41,2.82,;-4.08,2.82,;-5.41,3.59,;-3.31,4.16,;-4.85,1.49,)| | ||
| Structure | 
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