Reaction Details |
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Target | DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
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Ligand | BDBM518647 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TR-Fret Assay |
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IC50 | 4.30±n/a nM |
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Citation | Min, J; Scott, DC; Bhasin, D; Schulman, BA; Singh, B; Hammill, JT; Guy, RK Methods and compositions of inhibiting DCN1-UBC12 interaction US Patent US11116757 Publication Date 9/14/2021 |
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More Info.: | Get all data from this article, Assay Method |
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DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
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Name: | DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
Synonyms: | DCN1-UBC12 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | NEDD8-conjugating enzyme Ubc12 |
Synonyms: | 2.3.2.- | NEDD8 carrier protein | NEDD8-conjugating enzyme Ubc12 | UBC12 | UBC12_HUMAN | UBE2M | Ubiquitin-conjugating enzyme E2 M |
Type: | PROTEIN |
Mol. Mass.: | 20901.74 |
Organism: | Homo sapiens |
Description: | ChEMBL_118032 |
Residue: | 183 |
Sequence: | MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF
KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK
PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER
CLK
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Component 2 |
Name: | DCN1-like protein 1 |
Synonyms: | DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1 |
Type: | PROTEIN |
Mol. Mass.: | 30118.96 |
Organism: | Homo sapiens |
Description: | ChEMBL_117443 |
Residue: | 259 |
Sequence: | MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSL
DRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQ
EFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIA
YWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLI
DDFVEFARPQIAGTKSTTV
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BDBM518647 |
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n/a |
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Name | BDBM518647 |
Synonyms: | US11116757, No. A1 |
Type | Small organic molecule |
Emp. Form. | C28H37F3N4O3S |
Mol. Mass. | 566.679 |
SMILES | CCCC(C)N1CCC(CC1)N(Cc1cccc(CNS(=O)(=O)C=C)c1)C(=O)Nc1cccc(c1)C(F)(F)F |
Structure |
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