Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518898 (US11116757, No. A193) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM519032 (US11116757, No. B19) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50079170 (1-(1-Benzyl-piperidin-4-yl)-3-phenyl-urea | CHEMBL...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | <4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM519034 (US11116757, No. B21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518647 (US11116757, No. A1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NEDD8-activating enzyme E1 catalytic subunit (Homo sapiens) | BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged NAE1 expressed in baculovirus expression system after 90 mins in presence of FLAG-tagged NEDD8 by TR-FRET ... | J Med Chem 61: 2680-2693 (2018) Article DOI: 10.1021/acs.jmedchem.7b01277 BindingDB Entry DOI: 10.7270/Q29K4DVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518656 (US11116757, No. A2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245154 (CHEMBL4067795 | US11116757, No. A10) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Binding affinity for Adenosine A1 receptor using N-[3H] cyclohexyladenosine in rat forebrain membranes | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518671 (US11116757, No. A3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245227 (CHEMBL4077431 | US11116757, No. A4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245237 (CHEMBL4074213 | US11116757, No. A7) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a... | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245225 (CHEMBL4099097 | US11116757, No. A15) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a... | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245225 (CHEMBL4099097 | US11116757, No. A15) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245225 (CHEMBL4099097 | US11116757, No. A15) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245227 (CHEMBL4077431 | US11116757, No. A4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a... | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245131 (CHEMBL4094517 | US11116757, No. A5) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 55.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245148 (CHEMBL4077759 | US11116757, No. A6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a... | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245148 (CHEMBL4077759 | US11116757, No. A6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245225 (CHEMBL4099097 | US11116757, No. A15) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla... | J Med Chem 61: 2680-2693 (2018) Article DOI: 10.1021/acs.jmedchem.7b01277 BindingDB Entry DOI: 10.7270/Q29K4DVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245131 (CHEMBL4094517 | US11116757, No. A5) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a... | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245237 (CHEMBL4074213 | US11116757, No. A7) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 76.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245153 (CHEMBL4078685 | US11116757, No. A8) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 76.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245153 (CHEMBL4078685 | US11116757, No. A8) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a... | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518705 (US11116757, No. A9) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 78.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245154 (CHEMBL4067795 | US11116757, No. A10) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | US Patent | n/a | n/a | 78.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245140 (CHEMBL4103209 | US11116757, No. A11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 81.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245140 (CHEMBL4103209 | US11116757, No. A11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a... | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518708 (US11116757, No. A12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 82.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245130 (CHEMBL4086099 | US11116757, No. A13) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | US Patent | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518710 (US11116757, No. A14) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 85.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245225 (CHEMBL4099097 | US11116757, No. A15) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 88.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518714 (US11116757, No. A16) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 90.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518715 (US11116757, No. A17) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 95.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50460825 (CHEMBL4102019 | US11116757, No. A21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50576267 (CHEMBL4876194) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of DCN1 (unknown origin) dependent cullin neddylation assessed as decrease in NEDD8 transfer from UBE2M to CUL2 using CUL2 as substrate pr... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00035 BindingDB Entry DOI: 10.7270/Q2QC07CR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50460825 (CHEMBL4102019 | US11116757, No. A21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518716 (US11116757, No. A18) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50245130 (CHEMBL4086099 | US11116757, No. A13) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of biotin-labeled DCN1 (unknown origin) assessed as reduction in protein interaction with Ac-UBE2M12-AlexaFluor488 after 1 hr by TR-FRET a... | J Med Chem 61: 2694-2706 (2018) Article DOI: 10.1021/acs.jmedchem.7b01282 BindingDB Entry DOI: 10.7270/Q22V2JHZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518720 (US11116757, No. A20) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518718 (US11116757, No. A19) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50460825 (CHEMBL4102019 | US11116757, No. A21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50460827 (CHEMBL4077751 | US11116757, No. A43) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518722 (US11116757, No. A22) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50460853 (CHEMBL4229003 | US11116757, No. A37) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518725 (US11116757, No. A23) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1 (Homo sapiens) | BDBM50460806 (CHEMBL4226555 | US11116757, No. A88) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla... | J Med Chem 61: 2680-2693 (2018) Article DOI: 10.1021/acs.jmedchem.7b01277 BindingDB Entry DOI: 10.7270/Q29K4DVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518822 (US11116757, No. A118) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518726 (US11116757, No. A24) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM518727 (US11116757, No. A25) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (Homo sapiens) | BDBM50245223 (CHEMBL4085483 | US11116757, No. A26) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 163 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2736V2B | |||||||||||
More data for this Ligand-Target Pair |
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