| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
|---|
| Ligand | BDBM518718 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TR-Fret Assay |
|---|
| IC50 | 116±n/a nM |
|---|
| Citation |  Min, J; Scott, DC; Bhasin, D; Schulman, BA; Singh, B; Hammill, JT; Guy, RK Methods and compositions of inhibiting DCN1-UBC12 interaction US Patent US11116757 Publication Date 9/14/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
|---|
| Name: | DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
|---|
| Synonyms: | DCN1-UBC12 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | NEDD8-conjugating enzyme Ubc12 |
|---|
| Synonyms: | 2.3.2.- | NEDD8 carrier protein | NEDD8-conjugating enzyme Ubc12 | UBC12 | UBC12_HUMAN | UBE2M | Ubiquitin-conjugating enzyme E2 M |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 20901.74 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_118032 |
|---|
| Residue: | 183 |
|---|
| Sequence: | MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF
KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK
PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER
CLK
|
|
|
|---|
| Component 2 |
| Name: | DCN1-like protein 1 |
|---|
| Synonyms: | DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30118.96 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_117443 |
|---|
| Residue: | 259 |
|---|
| Sequence: | MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSL
DRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQ
EFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIA
YWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLI
DDFVEFARPQIAGTKSTTV
|
|
|
|---|
| BDBM518718 |
|---|
| n/a |
|---|
| Name | BDBM518718 |
|---|
| Synonyms: | US11116757, No. A19 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H45N3O |
|---|
| Mol. Mass. | 463.6978 |
|---|
| SMILES | CCCCCCc1ccc(NC(=O)N(Cc2ccccc2)C2CCN(CC2)C(C)CCC)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
